One of the most recent indication of PRP for facial aesthetic and rejuvenation is called Vampire Facelift. It has been used since 2006. The practice started off in USA, then spread to Korea. The treatment is good for the improvement of skin color, tone as well as the texture.
The PRP is rich in various Platelet Derived Growth Factors, PDGFs in short. There are important nine types of growth factors list below, but not exhaustive.
These growth factors, PDGF promote regeneration of fibroblast and keratinocyte and increased production of collagen and keratin respectively. PDGF also help in cellular division of fibroblast. The fibroblast is present in abundant in the connective tissues. Fibroblast also produce the extracellular matrix other than collagen.
The production of both cellular matrix and collagen is the very reason that it help to decrease the wrinkle for aesthetic purpose. Many of these growth factor has a specific function, but many also has a general overlapping function of wound healing.
In any treatment, if we can get our own tissue products from one site and use it to treat another types of injured tissue, it is the best and safest. This procedure is very conservative and minimally invasive. The face-lift effect is not comparable to the traditional classical face-lift surgery, but its effect is sufficient to bring about improvement in skin tone, texture and color.
The result can be seen within 3 weeks and improvement continue for the next 6 to 12 months as more collagen is being laid within the skin matrix. The result may last 1 to 2 years. The result is very natural and give a pleasing feel.
The area might be treated include the Crow’s feet, the cheeks peri-oral line, naso-labial or power line, jawline, neck and chest. The procedure can take 1 to 2 hours depending on the extend and complexity. For best result, repeat in 2 to four weeks. More the treatment, better is the result.
|Content of PRP
Whole blood after the spinning, we get RBC at the bottom, PPP at the top, PRP at the plasma and RBC interface.
|PRP contain many growth factors & cytokines:
· Transforming growth factor beta (TGFβ) – for cell division & attract stem cell to the wound
· Connective tissue growth factor (for wound healing)
· Insulin-like growth factor I (IGF-1)
· IGF-II, the insulin like growth factor II
· Vascular-endothelial growth factor (for organ regeneration)
· EGF, Epithelial growth factor
· Interleukin 8
· Fibroblast growth factor ( for wound healing/ aesthetics uses)
· Keratinocyte growth factor (wound healing/ aesthetics uses)
|Once the PRP proteins, growth factors, cytokines bind to cellular receptors of skin (as in aesthetics), tendon, ligament, fascia, muscle, and bone and cartilages (as in soft tissue injury), usually in such cell as fibroblast, endothelial cell and osteoblast, they activate inter-cellular events helping to activate the following processes of wound healing:|
|· Angiogenesis (proliferation of new blood vessels)
· Migration of stem cell to the injection area
· New cell proliferation
· Production of extra-cellular matrix
|Results start to be visible from 3 weeks. The effect can last up to 18 months.|