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Azelaic acid

Azelaic acid

Azelaic acid as a natural skin whitener, is widely used in cosmeceutical, or the cosmetic cream’s active ingredient.

The Clinic Laser & Cosmetic Surgery Ling has been using this ingredient safely for skin whitening treatment over the past 20 years, together with the PRP, filler (such as Vampire lift), Botox and thread lift.

Azelaic can be used together as a part of the formula for skin care products. The formula component ingredients are listed here includes:

Sources

Azelaic acid is a component of various grains like the barley used for drink, the wheat that forms the main Western diet and the rye. Azelaic acid is a naturally occurring dicarboxilic acid and is produced by a yeast called Pityrosporum ovale.

 

Azelaic acid for Melanin pigment brings about natural skin whitening.

Azelaic acid for Melanin pigment brings about natural skin whitening.

Concentration used

The application of azelaic acid comes in the form of cream for topical use. The typical concentration used for skin whitening formulation is 10 to 20%.

Indications of azelaic acid

  • Azelaic acid is commonly used to treat inflammatory condition such as acne.
  • It is often used successfully for the treatment for lentigines, PIH, melasma and rosacea (Policarpio and Lue, 2009).
  • Effective in treatment of hypermelanosis caused by various physical and chemical agents and factor. It is also effective in the treatment for other skin disorders characterized by abnormal proliferation of melanocytes.
  • It is also commonly used for skin whitening effectively.

The only problem of treatment with azelaic acid is that its therapeutic response is rather slow (Solano et al., 2006)

 

Mechanism of action

  • Study show that azelaic acid brings about skin whitening through its action as a melanin synthesis inhibitor. Azelaic acid is a rather weak competitive inhibitor of tyrosinase enzyme.
  • It is also shown to have an anti-proliferation and cytotoxic effect on pigment producing cell, the melanocytes (Pravez et al., 2007).
  • Azelaic acid is not able to induce depigmentation on normally pigmented skin, suggesting its selective anti-proliferation and cytotoxic action on abnormal melanocytes.